ABSTRACT
Background:Febrile seizures are among the leading cause of pediatric emergency hospital admission and affect 2% to 5% of pediatric population1,2 and are by far the most common type of seizure in childhood.Various risk factors are said to play a role in aetiology of FS are gender, developmental delay, maternal history of smoking, family history, bacterial and viral infections, certain vaccinations and iron deficiency, low serum sodium at the time of presentation. Preventive measure to remove such risk factor could lead to lower the incidence of febrile seizure.Objective: To study occurrence of predictive risk factors like gender, age, low birth weight in children with febrile seizure. To study fever and seizure pattern in above children. To observe positive family history pertaining to febrile seizure. Material And Methods:An observational prospective study was conducted in the tertiary care hospital over a 2 year period. Children aged 6 months to 60 months diagnosed as febrile seizure and admitted at pediatric ward were included in the study. A total of 69 patients were enrolled in the study. All information was collected from parents and indoor case sheets after taking verbal consent. Data was entered in Microsoft excel and analysis was carried out using SPSS version 21. Result:Gender wise amale predominance was seen. Youngerage group isa risk factor. Majority of children (92.8%) presented with simple FS with seizure duration less than 5 minutes. Majority (82.6 %) had fever for < 24 hour prior to FS. Positive family history of FS is observed in 20.2% children. Conclusion:Identification of predictive risk factor will help clinician to educate and counsel parents regarding seizure recurrence, prophylactic use of antipyretic and measures during seizure activity.
ABSTRACT
The present study was carried out to evaluate the antimicrobial activity of the crude methanolic extracts of Memecylon malabaricum Clarke. (leaves), Cochlospermum religiosum Linn. (leaves and flowers) and Andrographis serpyllifolia Vahl. (leaves) using the standard disc diffusion assay against eight strains of bacterial species, viz., Staphylococcus aureus, Salmonella typhi, Enterobacter aerogenes, Pseudomonas aeruginosa, Xanthomonas oryzae pv. oryzae, Xanthomonas axonopodis pv. malvacearum, Bacillus cereus and Micrococcus sp. The extracts of the plants at a concentration of 1.25 mg/disc showed minimum to moderate activity against both Gram positive and Gram negative bacteria indicating a broad spectrum activity. A preliminary phytochemical screening was conducted on the selected plant extracts using standard qualitative procedures that revealed the presence of several secondary metabolites. The extracts failed to show antioxidant activity by reducing power assay. The result indicates the potential usefulness of these plants especially Memecylon malabaricum and Cochlospermum religiosum, in treating microbial infections in humans and plants and justifies the need for further investigations and characterization of the bioactive compounds present in the methanolic extracts of the plants.